Chromatin Immunoprecipitation Uses

Chromatin Immunoprecipitation Assay / ChIP has the advantage of measuring protein DNA interactions of promoter regions with protein complexes in the natural genomic state. Moreover, the ChIP assay can directly provide information on the histone acetylase status of specific chromatin regions, and be used to study non-histone proteins, even ones that do not directly bind DNA. It also minimizes the chances of chromatin rearrangements during preparation and precipitation, and it can be used with gene-specific primers for increased sensitivity or with a specific probe, slot blot hybridization, for increased specificity.